IGeneticLab Test can Detect Dengue in the First 24Hours

New Delhi, 6 April 2018: Dengue is a mosquito-borne illness that can cause severe flu-like symptoms with possible complications like hemorrhage and shock. Dengue infection may progress to dengue hemorrhagic fever resulting in severe abdominal pain, vomiting, diarrhea, convulsions, bruising, and uncontrolled bleeding.The most severe form of the illness- dengue hemorrhagic shock- may lead to plasma leaking, fluid accumulation, respiratory distress, severe bleeding, and multiorganfailure. With such complications, fatality is significant. Hence, timely and correct diagnosis is critical.

According todata from the National Vector Borne Disease Control Programme, DGHS, there were157220 cases of Dengue last year- over a 5.5-fold increase from 2010 to 2017.Deaths due to dengue infection have more than doubled over the same period. Infact, there were 28000 more cases in India in 2017 as compared to 2016, makingthis disease a major public health concern. Delhi had the dubious distinctionof doubling the number of dengue cases in 2017 versus 2016. Alarmingly, thecity has already reported 15 cases this year leading experts to predict alarger number of cases in the monsoon of 2018.

Missed oreven delayed diagnosis can lead to severe complications due to dengue.Two-thirds of deaths from dengue are due to missed diagnosis necessitating useof a quick, reliable method for detection. Routine testing for Dengue is doneusing ELISA to detect Nonstructural protein 1 (NS1), IgMandIgG. NS1 can be usedfor detection in the 1st 5 days after infection whileIgMisdetected only after 3-5 days of illness in cases of primary infection andpersists for two or three months. IgG may appear in the same time-frame butpersists life-long. However, IgM/IgG detection is not very specific for dengueand may cause false positives due to cross-reactivity with other Flaviviruses.Additionally, none of these assays can be used for serotyping.

With itsinnovative Molecular assays, iGenetic Diagnostics can detect dengue virus inblood samples of patients at a very early stage of infection. This ensurestimely treatment resulting inbetter outcomes for the patient. The companyheadquartered in Mumbai applies advanced PCR-based technologies to look for thegenetic material of the pathogen in the patient’s sample. Dengue virus andhence, its RNA, is detectable in the blood from Day 1 to about Day 7. Thehighly sensitive method developed at iGenetic enables detection of dengue fromDay 1.

Dengue virushas 4 serotypes- DENV1, DENV2, DENV3 and DENV4. All serotypes are found inIndia. Of these, DENV2 and DENV3 are frequently associated withsevere disease accompanying secondary dengue infections. Once a person has beeninfected with one serotype, they have lifelong immunity from infection by thatserotype. However, if an individual gets a Dengue infection again with adifferent serotype, disease progression is accelerated and severe, therebyproving deadly.So iGenetichas also developed a rapid Molecular Diagnostictest that can identify the serotype of the virus.

“Dengue andother viral infections are difficult to diagnose using conventionalmicrobiological methods. Viral cultures are not commonly done by routine diagnosticlabs and serological methods have low sensitivity and specificity. We havesuccessfully employed Molecular Diagnostic approaches to accurately and rapidlydiagnose viral infections. Even other complex conditions like Septicemia andCNS infections are diagnosed in 24 hours at iGenetic. Speed andaccuracy of diagnosis are vital in critical care. Besides, our innovations helpus keep prices affordable so that these services can be used even in smallercities and villages.” saysMsArunima Patel, Founder and CEO, iGeneticDiagnostics.

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